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Research2

FEATURED RESEARCH

Therapeutic Research for Various Diseases via Macrophage Polarization Control

Targeting Fibrosis and Ovarian Cancer through Immune Microenvironment Modulation

Study on Fibrosis Improvement in Uterine and Lung Models

Figure 2-1

Restoration of Fibrotic Tissues via M1 to M2 Polarization

In uterine and lung fibrosis models, an imbalance in macrophage polarity is observed. By inducing a shift from M1 (pro-inflammatory) to M2 (pro-healing), tissue regeneration is promoted, leading to the restoration of normal tissue functions.

(Cell & Bio Sci, 2024; Patent No. 10-2635831)

Study on Therapeutic Effects in Ovarian Cancer Xenograft Models

Figure 2-2

Enhanced Anti-tumor Activity in Ovarian Cancer TME

Research utilizing ovarian cancer xenograft models demonstrates that promoting M1-like (anti-tumor) macrophage polarization, especially in combination with Paclitaxel, effectively suppresses tumor growth within the Tumor Microenvironment (TME).

(Patent Application No. 10-2024-0147947)

Key Findings

FIBROSIS RELIEF

M1 to M2 Shift

Successful restoration of uterine and pulmonary tissue by inducing M2 polarization.

CANCER IMMUNOTHERAPY

TME Modulation

Enhanced anti-tumor activity in ovarian cancer via M1 phenotype activation.

SYNERGY EFFECT

Chemo-Combination

Synergistic tumor suppression when combined with Paclitaxel treatment.

INTELLECTUAL PROPERTY

Patent Applied

Core technology protected under Patent No. 10-2635831 and others.

Research Focus Areas

  • Fibrosis icon

    Uterine & Pulmonary Fibrosis

    Tissue Regeneration Therapy

    Developing therapeutic strategies to reverse fibrotic changes in the uterus and lungs by modulating the macrophage-mediated inflammatory response.

  • Cancer icon

    Ovarian Cancer Xenograft Model

    Next-Gen Cancer Immunotherapy

    Researching the efficacy of macrophage polarization in suppressing ovarian cancer progression and improving the delivery of chemotherapeutic agents.

  • Immune icon

    Macrophage Plasticity

    M1/M2 Polarization Mechanism

    Investigating the molecular signals that govern the plastic nature of macrophages to switch between pro-tumor and anti-tumor states.

  • TME icon

    Tumor Microenvironment (TME)

    Immune Escape Inhibition

    Analyzing the interaction between tumor cells and macrophages to prevent immune evasion and enhance the body's natural defense mechanisms.