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Research1

FEATURED RESEARCH

Regenerative Therapy for Female Reproductive Diseases

Uterine Microenvironment Regulation Mechanism Study

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Figure 1

Histological and functional recovery of the uterine environment in Asherman’s Syndrome (AS) model using stem cells and their derivatives.

In AS endometrium, imbalanced macrophage polarity, hypoxia, and fibrosis are observed, leading to delayed implantation and miscarriage/fetal demise. CYP-A secreted from hPVSCs (human placenta-derived perivascular stem cells) modulates the HIF1α pathway to promote normal implantation and fetal growth, restoring balanced macrophage polarity, angiogenesis, and cell proliferation as seen in healthy endometrium.

(Molecular Therapy, 2020; Patent No. 10-2370535, 10-2477288)

Key Findings

STEM CELL THERAPY

hPVSCs + CYP-A

Human placenta-derived perivascular stem cells & Cyclophilin-A

KEY PATHWAY

HIF1α Pathway

Uterine environment normalization via hypoxia-inducible factor

THERAPEUTIC OUTCOME

Normal Implantation & Delivery

Successful fetal growth and live birth achieved

PATENTS

2 Registered

Patent No. 10-2370535, 10-2477288

Research Areas

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    Regenerative Therapy for Female Reproductive Diseases

    Stem Cell-Based Uterine Recovery

    Investigating histological and functional recovery of the uterine environment in Asherman's Syndrome (AS) models using stem cells and their derivatives. hPVSCs (human placenta-derived perivascular stem cells) and CYP-A modulate the HIF1α pathway to promote normal implantation and fetal growth.

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    Uterine Microenvironment Regulation

    Endometrial Cell Interactions

    Analyzing the interactions among epithelial cells, stromal cells, and pro-angiogenic factors in the endometrium to elucidate the mechanisms that establish normal receptivity during the implantation window.

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    Macrophage Polarity Balance

    Immune Environment Restoration

    Developing strategies to correct M1/M2 macrophage polarity imbalance observed in AS endometrium, restoring a balanced immune environment similar to that of healthy endometrium.

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    Hypoxia & Fibrosis Inhibition

    Tissue Regeneration Promotion

    Inhibiting hypoxia and fibrosis in AS environments using stem cell-derived factors, while promoting angiogenesis and cell proliferation to induce tissue regeneration.